Sindel was the queen of Edenia before Shao Kahn merged the realm with Outworld. Unwilling to serve under his rule after Kahn kills her husband King Jerrod during battle, she takes her own life. In order to merge Earthrealm and Outworld and thus start an invasion, Kahn (with the assistance of Shang Tsung) revives her on Earth, turning her into his loyalist queen with no memory of her past. After Kahn's defeat, Sindel's daughter, Kitana, tells her mother about her true past, causing Sindel to rebel against Kahn. With Edenia no longer part of Outworld, Sindel takes her rightful place on the throne. However, the forces of Shinnok soon storm the palace, capturing her, but Shinnok is then defeated by Earth warriors saving the peaceful realm. Edenia is again invaded, this time by the Dragon King, Onaga, who had resurrected Kitana and her slain Earthrealm allies and placed them under his control. Sindel is once again confined inside her own prison, this time guarded by her own daughter, but is freed by Jade. In the 2011 reboot, Sindel plays a more antagonistic role unaware of her true past. She kills several Earthrealm warriors, until she is destroyed by Nightwolf.
While MK3 was in production, she was nicknamed "Muchacha" and "The Bride" by the programmers before her official name was determined.
Sindel was ranked as third goofiest Mortal Kombat character by Topless Robot in 2011.