After accidentally burning down his house, Glenn takes his family — wife Jackie, hormone-addled 13-year-old Conor, power suit-wearing 11-year-old Courtney, Courtney’s overachieving assistant Wendy, and Canine the family's dog — on a cross-country road trip to tighten the family bond.
The show has a 1970's sensibility including the design of the Winnebago which is driven across the country. It was reportedly inspired by the 1971 ABC made-for-TV movie In Search of America that starred Jeff Bridges as a college dropout who drove a Winnebago across the country with his family. The show had a laugh track in early episodes but removed later at the request of the creators.
Former Disney chief executive Michael Eisner, who has put his own money into the project, pitched it to Nick at Nite rather than ABC. Eisner was quoted as saying the decision was based on Nick at Nite's record of nurturing shows.
Due to successful ratings, it was recently announced that Glenn Martin, DDS was renewed for a second season.
In November, 2010, the show won two Gemini Awards (Canadian Emmys)for best animated series, and best direction for an animated series (Ken Cunningham - "The Tooth Will Set You Free.")